From Fertilisation to Implantation



Some of the 'hot' red squares in this graphic are active - The CD-Rom "An Introduction to Assisted Reproduction" from the IFC Resource centre provides a more extended discussion.

Fertilisation and embryo deveopment graphics See more detail and explanation of the pronucleate stage See more detail about fertilisation

In conception as a result of sexual intercourse the egg and sperm usually meet high up in the fallopian tube. If fertilisation does takes place, the fertilized egg develops into an embryo and moves down the fallopian tube towards the uterus - by the time it reaches the uterus it is ready to implant in the endometrium which has thickened ready to receive the embryo. It is the embryo which initiates the implantation process and it is known that between 50% & 70% of embryos never do implant - there is a tremendous natural wastage.

In IVF the fertilisation and early embryo development takes place in the laboratory (in culture medium). Embryos are transferred to the uterus during embryo transfer at the early cleavage stages or, with the development of new culture techniques, at the blastocyst stages.

One in six couples have difficulties in having a baby and may seek help through assisted reproductive medicine. In GIFT the sperm & eggs are transferred to the fallopian tubes so that fertilisation takes place within the body and the embryos can benefit from the natural secretions and contact with the cells of the fallopian tubes & upper uterus. In Artificial insemination sperm may be placed at the top of the vagina as semen or (as a culture of cells) within the cervical canal or directly into the uterus.

See also follicular stimulation.